A new way to restrict the ability of cancer to use glucose for energy has been identified; and it could be one main therapeutic strategy.
Cancer cells consume exorbitant amounts of glucose, a key source of energy, and shutting down this glucose consumption has long been considered a logical therapeutic strategy.
However, good pharmacological targets to stop cancers’ ability to uptake and metabolize glucose are missing. In a new study published in Cell Reports, a team of University of Colorado Cancer Center researchers, led by Matthew Galbraith, and Joaquin Espinosa, finally identifies a way to restrict the ability of cancer to use glucose for energy.
Over-expression of the gene CDK8 is linked to the development of many cancers including colorectal cancer, melanoma, and breast cancer, where it regulates pathways that drive the growth and survival of cancer cells.
Although a number …
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